Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegans
D. F. Bennett, A. Goyala, C. Statzer, C. W. Beckett, A. Tyshkovskiy, V. N. Gladyshev, C. Y. Ewald, J. P. de Magalhaes
This study identifies rilmenidine as a caloric restriction mimetic that extends lifespan in C. elegans by activating the I1-imidazoline receptor and modulating pathways involved in stress resistance and autophagy.
bioRxiv · Oct 13, 2021 · PreprintPharmacology & Toxicology