Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines
J. Kosonen, A. Eskelinen, G. Orozco, P. Nieminen, D. Anderson, A. Grodzinsky, R. Korhonen, P. Tanska
This paper develops a 2-D mechanobiological model to simulate early post-traumatic osteoarthritis by integrating necrosis, reactive oxygen species, and inflammatory cytokines, showing partial recovery of proteoglycan content when inflammation is mitigated.
bioRxiv · Jun 29, 2022Biophysics