D. Anderson

Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of Streptococcus mutans

The paper identifies the MecA interactome of Streptococcus mutans using mass spectrometry and split luciferase complementation assays, revealing both Clp-dependent and proteolysis-independent regulatory mechanisms.

Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines

This paper develops a 2-D mechanobiological model to simulate early post-traumatic osteoarthritis by integrating necrosis, reactive oxygen species, and inflammatory cytokines, showing partial recovery of proteoglycan content when inflammation is mitigated.

Half-calcified Calmodulin Promotes Basal Activity and Inactivation of the Calcium Channel CaV1.2.

The paper identifies a half-calcified calmodulin species that promotes CaV1.2 channel activity and inactivation by interacting with specific residues in the IQ motif.

Maternal diet and gut microbiota influence predisposition to cardiovascular disease in the offspring

The paper shows that maternal fibre intake during pregnancy influences offspring cardiovascular health by shaping the gut microbiome and inducing epigenetic changes in the offspring's heart.

Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease

This paper develops the first genetic system for Parvimonas micra, enabling molecular studies of its role in disease.

GAIT BIOMECHANICS OF RABBITS WITH EITHER ACHILLES OR TIBIALIS CRANIALIS ARTIFICIAL TENDONS

This study evaluates the biomechanics of rabbits with artificial Achilles or tibialis cranialis tendons, finding functional differences in ankle angles and recovery rates between the two groups.

Peroxide antimalarial drugs target redox homeostasis in Plasmodium falciparum infected red blood cells

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.

The paper identifies 389 small molecules and 813 host targets that inhibit SARS-CoV-2 infection through in vitro and in vivo testing, using computational integration of drug activity and cellular networks.

Evaluation of a polymeric composite bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect

This paper evaluates a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in contaminated bone defects, showing effective bacterial eradication and no adverse effects on osteogenic properties.

Seeding of outbreaks of COVID-19 by contaminated fresh and frozen food

The paper was withdrawn due to prior regulatory approval issues, and the authors request it not be cited.

Fully Implanted Prostheses for Musculoskeletal Limb Reconstruction after Amputation: An In Vivo Feasibility Study

This study tests the feasibility of implanting a limb prosthesis entirely within living skin in rabbits and identifies surgical approaches for successful healing.

Identification of a long non-coding RNA regulator of liver carcinoma cell survival

The paper identifies a long non-coding RNA, ASTILCS, critical for HCC cell survival and overexpressed in patient tumors.

Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.