Bacterial deamidases modulate ubiquitin structure and dynamics to dysregulate ubiquitin signaling
R. Agrata, P. Mohanty, A. Ravichandran, S. Kumari, N. Varshney, A. GS, K. Chauhan, J. Li, K. Chakrabarti, R. A. Byrd, R. Das
This study shows that deamidation of ubiquitin by bacterial enzymes creates salt bridges that disrupt its structure and dynamics, impairing ubiquitin signaling.
bioRxiv · May 22, 2023 · PreprintBiochemistry