S. Kumari

Expression Pattern of Epilepsy Associated Genes as a Common Pathological Signature in PTE and SE models and possible therapeutics via an in-silico approach

This study identifies a common gene expression signature in epilepsy models and suggests Fisetin as a potential multi-target therapeutic via in-silico analysis.

P66Shc Mediates SUMO2-induced Endothelial Dysfunction

This study identifies SUMO2-mediated modification of p66Shc as a mechanism causing endothelial dysfunction and oxidative stress in hyperlipidemia.

WASP facilitates tumor mechanosensitivity in T lymphocytes

This study identifies WASP as a key mediator of mechanosensitivity in CTLs, linking mechanical cues from target cells to TCR signaling and immune response.

A single-dose intramuscular immunization of pigs with lipid-nanoparticle DNA vaccines based on the hemagglutinin antigen confers complete protection against challenge infection with the homologous influenza virus strain

This study shows that lipid-nanoparticle DNA vaccines encoding hemagglutinin protect pigs fully against homologous IAV-S challenge with minimal viral shedding.

Measuring RBC deformability and its heterogeneity using a fast microfluidic device

The paper introduces a microfluidic device to measure RBC deformability and Young's modulus, showing stiffer RBCs deflect more and enabling sorting based on deformability.

Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection

This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.

Bacterial deamidases modulate ubiquitin structure and dynamics to dysregulate ubiquitin signaling

This study shows that deamidation of ubiquitin by bacterial enzymes creates salt bridges that disrupt its structure and dynamics, impairing ubiquitin signaling.

Pump-free and high-throughput generation of monodisperse hydrogel beads by microfluidic step emulsification for dLAMP-on-a-chip

This paper develops a pump-free microfluidic method to generate monodisperse hydrogel beads for dLAMP-on-a-chip, enabling high-throughput nucleic acid amplification with minimal sample volume.

Biophysical Characterization and Interaction study of WhiB6 Protein of Mycobacterium tuberculosis with Nucleic Acid

This study characterizes the biophysical interaction between WhiB6 protein and espA promoter DNA using multiple spectroscopic methods, revealing structural changes and potential therapeutic targets.

Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA

This study shows that Msi2 induces cardiac hypertrophy and heart failure by causing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

This study shows that the BNT162b2 mRNA vaccine induces temporary salivary IgA with strong neutralizing activity against SARS-CoV-2.

Rice WRKY13 TF protein binds to motifs in the promoter region to regulate downstream disease resistance-related genes

This study identifies downstream genes regulated by WRKY13 TF in rice through promoter analysis, motif detection, and molecular docking, revealing its role in disease resistance.

In Vivo Biocompatibility of ZIF-8 for Antigen Slow Release via Intranasal Administration

This study evaluates the in vivo biocompatibility of ZIF-8 for antigen slow release via intranasal administration, finding no significant adverse effects on blood serum proteins, lung function, or tissue morphology.

Anomalous diffusion of E. coli under microfluidic confinement and chemical gradient

This study investigates how confinement and chemical gradients affect E. coli motility, finding super-diffusive behavior under these conditions.

Genomewide basis for nitrogen use efficiency in contrasting genotypes of rice

This study compares transcriptomes of rice genotypes with contrasting nitrogen use efficiency under urea treatment, identifying common and specific gene expression patterns and their association with agronomic performance.

Autophagy initiation triggers p150Glued-AP-2β interaction on the lysosomes to facilitate their transport.

This study shows that autophagy initiation promotes p150Glued-AP-2β interaction on lysosomes, enhancing their transport via dynein.

Affinity-engineered human antibodies detect celiac disease gluten pMHC complexes and inhibit T-cell activation

The paper describes the engineering of high-affinity human antibodies that recognize gluten epitopes bound to HLA-DQ2.5 and inhibit T-cell activation in celiac disease.

Conjugates for use in peptide therapeutics: a systematic review and meta-analysis

This paper reviews and analyzes conjugates that extend therapeutic peptide half-life, finding glycosaminoglycans and engineered peptides offer significant improvements over PEGylation.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

iTaxoTools 0.1: Kickstarting a specimen-based software toolkit for taxonomists

iTaxoTools 0.1 provides a user-friendly software toolkit for alpha-taxonomic tasks, including species delimitation and diagnosis, with six GUI-based programs and new Python implementations of taxonomic algorithms.

Microbiome-Gut-Brain-Axis communication influences metabolic switch in the mosquito Anopheles culicifacies

This study shows that the gut microbiome influences brain function and metabolic changes in mosquitoes through a microbiome-gut-brain axis.

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice

This study shows that Lactobacillus rhamnosus reduces bone loss and improves bone health in Ovx mice by modulating Treg and Th17 cell balance and cytokine profiles.

The Response of Bacterial Flagellar Motor to Stepwise Increase in NaCl Concentration

This study examines how increasing NaCl concentration affects the flagellar motor speed and switching rates in E. coli and Salmonella enteritidis, revealing significant changes in motor behavior under high osmolarity conditions.

NBS1-CtIP-Mediated DNA End Resection Regulates cGAS Binding to Micronuclei

The paper shows NBS1-CtIP-mediated DNA end resection prevents cGAS from binding to micronuclei by modifying chromatin architecture.

A testis-specific Heme Peroxidase HPX12 regulates male fertility in the mosquito Anopheles stephensi

This study identifies HPX12, a testis-specific heme peroxidase in Anopheles stephensi, as critical for male fertility by maintaining antioxidant balance and preventing ROS-induced sperm defects.

Evaluation of Seed or Grain Storage Technologies from Indian Farming Societies Using A Hybrid and Multi-Attribute Approach

This study evaluates traditional and improved grain storage technologies in Indian farming communities using a hybrid multi-attribute approach to assess their performance and guide improvements.

Salivary AsHPX12 influence pre-blood meal associated behavioral properties in the mosquito Anopheles stephensi

This study shows that silencing AsHPX12 in Anopheles stephensi mosquitoes increases host attraction but reduces blood meal acquisition by altering probing behavior and salivary protein release.

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

A CD25-dependent IL-2 mutein selectively expands regulatory T cells and provides potent and targeted control of autoimmunity.

Investigation of a night soil compost psychrotrophic bacterium Glutamicibacter arilaitensis LJH19 for its safety, efficient hydrolytic and plant growth-promoting potential

An allosteric hot-spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling

This paper identifies an allosteric hot-spot in ZAP-70's tandem-SH2 domain that regulates T-cell signaling by enabling cooperative ligand binding, with mutations disrupting this process and causing autoimmune arthritis.