Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
L. Martinez-Ruiz, J. Florido, C. Rodriguez-Santana, A. Lopez-Rodriguez, A. Guerra-Librero, B. I. Fernandez-Gil, P. Garcia-Tarraga, J. M. Garcia-Verdugo, F. Oppel, H. Sudhoff, D. Sanchez-Porras, A. Ten-Esteve, J. Fernandez-Martinez, P. Gonzalez-Garcia, I. Rusanova, , G. Escames
This study shows that intratumoral melatonin injection enhances tumor regression in head and neck cancer models by increasing mitochondrial oxidative stress and improving cisplatin efficacy.
bioRxiv · Jul 17, 2023Cancer Biology