Trypanosoma cruzi persisters that survive benznidazole treatment in vitro and in vivo are in a transient non-proliferative state.
S. Jayawardhana, A. I. Ward, A. F. Francisco, M. D. Lewis, M. C. Taylor, J. M. Kelly, F. Olmo
This study identifies benznidazole-treated Trypanosoma cruzi persisters as transient non-proliferative parasites, not localized to specific tissues, and suggests their survival may involve DNA damage response or pre-existing non-replicative states.
bioRxiv · Aug 23, 2023 · PreprintMicrobiology