A. Khan

Genome-targeted enrichment and sequencing of human-infecting Cryptosporidium spp.

The paper develops and validates a set of 100,000 RNA baits (CryptoCap_100k) to enrich Cryptosporidium DNA from clinical and environmental samples, improving read mapping, coverage, and variant analysis while reducing costs.

Cyclin A2 Induces Cytokinesis in Human Adult Cardiomyocytes and Drives Reprogramming in Mice

This study shows that Cyclin A2 induces cytokinesis in adult human cardiomyocytes and drives reprogramming in mice through transcriptomic analysis.

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

This study investigates whether inhaled cannabidiol (CBD) can reverse fentanyl addiction and modulate neuroinflammation in a mouse model.

Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

Active Microtubule-Actin Crosstalk Mediated by a Nesprin-2G-Kinesin Complex

This study identifies N2G as an F-actin bundler and kinesin-1 activator that mediates active microtubule-actin crosstalk, crucial for nuclear positioning.

Extensive population structure highlights an apparent paradox of stasis in the impala (Aepyceros melampus)

This study sequenced impala genomes to investigate evolutionary stasis, finding genetic structure and reduced natural selection in eastern populations compared to southern African ones.

Reanalysis of sequences of alleged Javan tiger highlights the difficulties in studying big cats and the need for high throughput sequencing.

The paper reanalyses DNA sequences from alleged Javan tiger sightings, finds unreliable results, and emphasizes the need for high-throughput sequencing and reliable databases for big cat conservation.

Elevated Lactate in the AML Bone Marrow Microenvironment Polarizes Leukemia-Associated Macrophages via GPR81 Signaling

This study identifies lactate as a key factor in AML-induced immunosuppression by polarizing leukemia-associated macrophages via GPR81 signaling.

A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss

The paper identifies INS-7, an ancestral insulin superfamily peptide in C. elegans, as a gut-to-brain signal that counteracts neuronally driven fat loss during fasting.

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

SETD2 maintains nuclear lamina stability to safeguard the genome

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

This study identifies FLVCR1 as a transporter for choline and ethanolamine, revealing structural insights into its dual role in the Kennedy pathway.

Serial colonization shapes genetic variation and defines conservation units in Asian elephants

This study identifies five conservation units in Asian elephants using whole-genome data, revealing serial colonization patterns and genetic diversity gradients from north to south in India.

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium

This study identifies LiaX as a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium and validates its use through ELISA and genomic analysis of clinical isolates.

An in-silico approach to identify bioactive phytochemicals from Houttuynia cordata Thunb. As potential inhibitors of Human Glutathione Reductase

This study identifies three phytochemicals from Houttuynia cordata as potential inhibitors of human glutathione reductase through molecular docking and dynamics simulations.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

A multipotent cell type from term human placenta

The paper identifies multipotent CDX2 cells from term human placentas that can differentiate into cardiovascular lineages and restore cardiac function in a mouse model.

Molecular Basis of Cell Membrane Adaptation in Daptomycin-Resistant Enterococcus faecalis

This study identifies the role of cardiolipin synthase and the LiaFSR system in daptomycin resistance by redistributing anionic phospholipids in Enterococcus faecalis.

Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Diceros bicornis michaeli)

The paper compares the genetic impacts of natural dispersal and translocation in eastern black rhinoceros, finding lower inbreeding in dispersers but higher deleterious mutation load in translocated offspring.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

This study shows germline variants influence somatic evolution in breast cancer by modulating immunoediting, affecting tumor subtype and metastatic potential.

Lights, Camera, Mirrors, Action! Toolbox for 3D Reconstruction and Analysis Using a Single Camera and Planar Mirrors

The paper introduces a software toolbox for 3D reconstruction using a single camera and planar mirrors, enabling accurate analysis of high-speed animal movements.

High-level ceftazidime-avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant

The paper identifies a novel CMY-185 beta-lactamase variant in E. coli that confers high-level resistance to ceftazidime-avibactam through specific amino acid substitutions.

Carbohydrate distribution via SWEET17 is critical for Arabidopsis inflorescence branching under drought

The paper identifies SWEET17's role in carbohydrate distribution to support inflorescence branching under drought stress in Arabidopsis.

The vacuolar sugar transporter EARLY RESPONSE TO DEHYDRATION 6-LIKE4 regulates fructose signaling and plant growth

The paper shows that ERDL4 regulates fructose homeostasis, affecting plant growth and cold tolerance in Arabidopsis.

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid Arthritis.

This study shows that 3D environments influence fibroblast inflammation in rheumatoid arthritis, with soft hydrogels promoting a resolving phenotype and stiff scaffolds restoring inflammatory profiles.

Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions

The paper characterizes two new TRB family members in Arabidopsis thaliana, showing they have distinct localization but similar interactions with telomerase and PRC2 complexes.

Possible Self-awareness in Wild Adelie Penguins Pygoscelis adeliae

This study investigates self-awareness in wild Adelie penguins using mirror tests in their natural environment, suggesting potential self-recognition and social awareness.

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.