Author

A. Isaev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:E. coli· 1

Frequent Co-Authors

K. Severinov· 2 shared A. Andriianov· 1 shared A. B. Graham· 1 shared A. Bernheim· 1 shared A. Chechenina· 1 shared A. Drobiazko· 1 shared A. Livenskyi· 1 shared A. Santiago-Frangos· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

K. Severinov

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2 papers

Recent·Most cited

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

N. Burman, S. Belukhina, F. Depardieu, R. A. Wilkinson, M. Skutel, A. Santiago-Frangos, A. B. Graham, A. Livenskyi, A. Chechenina, N. Morozova, T. Zahl, W. S. Henriques, M. Buyukyoruk, C. Rouillon, L. Shyrokova, , A. Isaev

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

bioRxiv · Jan 2, 2024 · PreprintBiochemistry

Phage T3 overcomes the BREX defence through SAM cleavage and inhibition of SAM synthesis

A. Andriianov, S. Triguis, A. Drobiazko, N. Sierro, N. V. Ivanov, M. Selmer, K. Severinov, A. Isaev

This study shows that bacteriophage T3 evades BREX defence by degrading SAM and inhibiting its synthesis, revealing SAM's role as a co-factor in phage defence systems.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology