C. Rouillon

The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease

This study identifies the SAVED domain of CalpL as a ring nuclease that cleaves cA4, revealing its role in regulating the CRISPR defense system.

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands

This study shows CAF-1 deposits histones on both DNA strands during replication but uses different mechanisms on leading and lagging strands.

SAVED by a toxin: Structure and function of the CRISPR Lon protease.

The paper reports the crystal structure of CRISPR-Lon, a protein that activates by binding cA4 and cleaves CRISPR-T to release a nuclease-like fragment.

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

The paper examines how host and viral enzymes regulate cyclic nucleotide levels and infection outcomes in type III CRISPR systems.

A type III CRISPR ancillary ribonuclease degrades its cyclic oligoadenylate activator

The paper identifies TTHB144 as a self-limiting CRISPR ribonuclease that degrades its cyclic oligoadenylate activator, providing a mechanism to terminate RNA degradation after viral infection.

Ring nucleases deactivate Type III CRISPR ribonucleases by degrading cyclic oligoadenylate

The paper identifies a Ring nuclease that degrades cyclic oligoadenylate (cOA) to deactivate Type III CRISPR ribonucleases and terminate the antiviral state.