A. Bernheim

A family of lanthipeptides with anti-phage function

The paper identifies a family of over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage function, demonstrating their conservation and novel compound production.

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons

This study identifies evolutionary links between bacterial IS110 transposons and archaeal/eukaryotic RNA modification systems, suggesting RNA-guided mechanisms evolved from transposon components.

Strain intrinsic properties and environmental constraints together shape Escherichia coli dynamics and diversity over a twenty-year human gut time series

This study tracks E. coli dynamics in a human gut over 20 years, showing how strain properties and environmental factors influence diversity and persistence.

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

Predicting phage-bacteria interactions at the strain level from genomes

This paper predicts phage-bacteria interactions at the strain level using genomic data from Escherichia isolates and shows tailored phage cocktails are more effective.

Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold

This study investigates the evolution of viperin genes across prokaryotes and eukaryotes, revealing their conservation, diversification mechanisms, and immune functions.

Genomic characterization of the antiviral arsenal of Actinobacteria

This study systematically identifies anti-phage defense systems in Actinobacteria using DefenseFinder, revealing differences in system distribution and prevalence compared to other bacteria.

The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic membranes, shedding light on the emergence of eukaryogenesis

This study shows Asgard archaeal ESCRT-III proteins form helical filaments and remodel eukaryotic-like membranes, supporting their role in eukaryogenesis.

An expanding arsenal of immune systems that protect bacteria from phages

This study identifies 21 new bacterial defense systems against phages through genomic analysis and experiments, revealing novel protein domains and toxin-antitoxin mechanisms involved in anti-phage immunity.

Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion

The paper shows DSR proteins deplete NAD+ during phage infection, inhibiting propagation, and identifies SIR2 domains as effector NADases in bacterial immunity.

Systematic and quantitative view of the antiviral arsenal of prokaryotes

The paper develops DefenseFinder to systematically analyze anti-phage systems in prokaryotes, revealing average of five systems per genome across 20,000 genomes.

Prophage-encoded hotspots of bacterial immune systems

The paper identifies prophage-encoded hotspots as a source of novel anti-phage systems and validates their defense activity across bacterial species.

Nano-particles carried by multiple dynein motors: A Self-Regulating Nano-Machine

The paper studies nano-particles with dynein motors that self-regulate their transport, showing helical motion and efficient obstacle bypassing.

Bacterial retrons function in anti-phage defense

This study identifies retrons as anti-phage defense systems in bacteria, showing they confer phage resistance through a three-component mechanism involving RT, non-coding RNA, and an effector protein.

Inhibition of NHEJ repair by type II-A CRISPR-Cas systems

The paper investigates the interaction between NHEJ repair and type II-A CRISPR-Cas systems, finding that Csn2 inhibits NHEJ while NHEJ does not affect CRISPR-Cas.