Combined Right Ventricular Preload and Afterload Challenge Induces Contractile Dysfunction and Ventricular Arrhythmia in an Age-dependent Manner in Isolated Hearts of Dystrophin-deficient Mice
A. J. Behrmann, J. Cayton, M. Hayden, M. Lambert, Z. Nourian, K. Nyanyo, L. Hanft, M. Krenz, K. McDonald, T. L. Domeier
This study shows that dystrophin-deficient mice exhibit age-dependent RV contractile dysfunction and arrhythmia under preload/afterload challenge, with greater damage in middle-aged hearts.
bioRxiv · Nov 14, 2023 · PreprintPhysiology