BiochemistrybioRxiv
Identification of ubiquitin variants that inhibit the E2 ubiquitin conjugating enzyme, Ube2k
A. J. Middleton, J. Teyra, J. Zhu…·C. L. Day
The paper identifies ubiquitin variants that inhibit Ube2k by binding to a hydrophobic cleft, blocking ubiquitin transfer and enzyme activation.
DOI 10.1021/acschembio.1c00445