S. S. Sidhu

This study determines the structure of ROR2's CRD and Kr domains, revealing a novel mechanism for WNT5A signaling and identifying the CRD's role in ROR2 function and secretion.

This study identifies surface substitutions that enhance the crystallisation of Fab:antigen complexes by combining surface entropy reduction with phage-display technology and previously reported substitutions.

The paper develops conformation-specific probes to profile activated cullin-RING ligase networks, revealing differential regulation across cell types and activation pathways.

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

This study uses in vivo CRISPR screens to identify USP15 and SCAF1 as novel tumor suppressors in pancreatic cancer, with potential therapeutic implications.

This study develops a tetravalent antibody format that neutralizes SARS-CoV-2 variants with high potency and breadth, surpassing conventional bivalent antibodies.

The paper identifies novel N-terminal motifs recognized by Gid4 and Gid10 E3 ligases and shows how structural flexibility and substrate context influence ubiquitylation efficiency.

The paper identifies ubiquitin variants that inhibit Ube2k by binding to a hydrophobic cleft, blocking ubiquitin transfer and enzyme activation.

The paper generates a new Fzd2 flox mouse model to investigate tissue-specific roles of Fzd2, resolving contradictions in previous global knockout studies.

This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.

The paper describes synthetic monoclonal antibodies that neutralize SARS-CoV-2 by binding to the spike protein and blocking ACE2 receptor interaction, showing potent antiviral activity.

This study identifies MMD-associated RNF213 SNPs as dominant negative alleles that impair ubiquitylation, suggesting reduced E3-ligase activity as central to MMD pathogenesis.

This study uses laboratory evolution to infer protein structures by analyzing residue interactions from evolved sequences.

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.