C. L. Day

Structural and biophysical characterisation of ubiquitin variants that specifically inhibit the ubiquitin conjugating enzyme Ube2d2

The paper identifies ubiquitin variants that inhibit Ube2d2, showing structural and biophysical properties that suggest potential for developing selective E2 enzyme inhibitors.

Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection

The paper identifies Rare Variable Mtb Antigens (RVMA) that induce Th17 responses in human TB infection, suggesting their potential as vaccine antigens to enhance Th17 immunity.

Identification of ubiquitin variants that inhibit the E2 ubiquitin conjugating enzyme, Ube2k

The paper identifies ubiquitin variants that inhibit Ube2k by binding to a hydrophobic cleft, blocking ubiquitin transfer and enzyme activation.

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.

This study investigates how CD4 and CD8 co-receptors affect the functional avidity and activation of CD1b-restricted T cells specific for mycobacterial lipid antigens, revealing distinct functional profiles and proliferation patterns.

A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling

This paper identifies a previously unknown TOG domain in MEKK1 that binds curved tubulin heterodimers, and shows mutations disrupting this interaction are enriched in tumors.

Unbiased Definition Of A Shared T-Cell Receptor Motif Enables Population-Based Studies Of Tuberculosis

The paper identifies a shared T-cell receptor motif specific for a mycobacterial lipid antigen, associated with tuberculosis and independent of host genetic background.