Author

A. J. Severin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:phylogenetics / evolution· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

D. G. Sashital· 2 shared K. Murugan· 2 shared A. S. Seetharam· 1 shared A. Seetharam· 1 shared J. M. Serb· 1 shared K. E. McElroy· 1 shared R. E. Masonbrink· 1 shared S. Chudalayandi· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

D. G. Sashital

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Author profile →

3 papers

Recent·Most cited

Chromosome-level genome assembly of the disco clam, Ctenoides ales, a first for the bivalve order Limida

K. E. McElroy, R. E. Masonbrink, S. Chudalayandi, A. J. Severin, J. M. Serb

This paper presents the first chromosome-level genome assembly of the disco clam, Ctenoides ales, from the bivalve order Limida, which lacks genomic resources, and reports its mitochondrial genome and opsin inventory.

bioRxiv · Mar 1, 2024 · PreprintEvolutionary Biology

High-throughput in vitro specificity profiling of natural and high-fidelity CRISPR-Cas9 variants

K. Murugan, A. S. Seetharam, A. J. Severin, D. G. Sashital

This study compares cleavage activities and specificities of natural and engineered Cas9 variants using a high-throughput in vitro assay, revealing differences in off-target nicking and DSB formation.

bioRxiv · May 12, 2020 · PreprintBiochemistry

Pervasive off-target and double-stranded DNA nicking by CRISPR-Cas12a

K. Murugan, A. Seetharam, A. J. Severin, D. G. Sashital

This study investigates Cas12a cleavage specificity, revealing pervasive off-target nicking and double-stranded DNA degradation, which may impact its use in genome editing.

bioRxiv · Jun 2, 2019 · PreprintBiochemistry