Author

K. Murugan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

A. J. Severin· 2 shared D. G. Sashital· 2 shared A. S. Seetharam· 1 shared A. Seetharam· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 5 mutual co-author links

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2 shared papersBiochemistry

A. J. Severin

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2 papers

Recent·Most cited

High-throughput in vitro specificity profiling of natural and high-fidelity CRISPR-Cas9 variants

K. Murugan, A. S. Seetharam, A. J. Severin, D. G. Sashital

This study compares cleavage activities and specificities of natural and engineered Cas9 variants using a high-throughput in vitro assay, revealing differences in off-target nicking and DSB formation.

bioRxiv · May 12, 2020 · PreprintBiochemistry

Pervasive off-target and double-stranded DNA nicking by CRISPR-Cas12a

K. Murugan, A. Seetharam, A. J. Severin, D. G. Sashital

This study investigates Cas12a cleavage specificity, revealing pervasive off-target nicking and double-stranded DNA degradation, which may impact its use in genome editing.

bioRxiv · Jun 2, 2019 · PreprintBiochemistry