Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery
M. Herrera, J. Kim, Y. Eygeris, A. Jozic, G. Sahay
This study uses a Gal8-GFP reporter system to compare endosomal escape efficiency of lipid nanoparticles with cholesterol versus phytosterols, finding that LNP-Sito shows significantly enhanced escape.
bioRxiv · Dec 2, 2020Bioengineering