A. Mukherjee

Dynamic and decay kinetics of H3 variants in live cells reveal the pivotal role of HIRA/NSD2 in maintaining the distinct H3.3 specific chromatin landscape

This study uses live-cell imaging to analyze H3.3 and H3.1 dynamics, revealing that HIRA and NSD2 regulate their turnover and mobility, with H3.3 showing faster decay and dependence on transcriptional activity.

Impact of Species-Specific Plant Growth-Promoting Rhizobacteria (PGPR) on Maize (Zea mays) Phenotypic and Biochemical Diversity

This study evaluates the impact of four PGPR species on maize growth and biochemical parameters, finding significant increases in chlorophyll, enzymes, and yield.

Non-Electrostatic Basis for an Artificial Metalloenzyme Catalysis

This study identifies the catalytically active conformation of an artificial metalloenzyme through simulations and calculations, revealing non-electrostatic interactions that enable high catalytic efficiency.

A dual-gene reporter-amplifier architecture for enhancing the sensitivity of molecular MRI by water exchange

This paper develops a dual-gene reporter-amplifier system to enhance MRI sensitivity by using Aqp1 to facilitate water exchange, enabling detection of low-abundance Oatp1b3-expressing cells.

Exploring the potential of water channels for developing MRI reporters and sensors without the need for exogenous contrast agents

This study identifies new water channels as diffusion-weighted MRI reporters and develops sensors for protease activity without exogenous contrast agents.

Checkpoint-independent association of Mad3BUBR1 with Stu1CLASP directs homolog alignment in meiosis I

This study identifies a checkpoint-independent role for Mad3BUBR1 in promoting homolog alignment during meiosis I through its interaction with Stu1CLASP.

Analysing the distribution of SARS-CoV-2 infections in schools: integrating model predictions with real world observations

This paper develops an analytical model to predict SARS-CoV-2 outbreak sizes in schools by integrating model predictions with real-world infection data from Ontario, Canada.

Engineering water exchange is a safe and effective method for magnetic resonance imaging in diverse cell types

This study shows that overexpressing Aquaporin-1 in diverse cell lines does not harm cell viability or function, making it a safe tool for magnetic resonance imaging.

Membrane potential mediates the cellular response to mechanical pressure

This study shows that membrane potential mediates cellular responses to mechanical pressure by regulating cell growth, proliferation, and elimination through Hippo and MAPK pathways.

Structure of the portal complex from Staphylococcus aureus Pathogenicity Island 1 transducing particles in situ and in solution

The paper determines the structure of the portal complex from Staphylococcus aureus Pathogenicity Island 1 transducing particles using cryo-electron microscopy, revealing its interaction with the capsid.

Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

This study shows that turgor pressure in E. coli increases with growth rate and directly controls cell wall biosynthesis rate.

Plasticity of growth laws tunes resource allocation strategies in bacteria

This study shows that nutrient quality in bacteria is a plastic property shaped by proteome allocation, not a fixed biochemical constraint, and can be modified through genetic engineering.

Long-term history dependence of growth rates of E. coli after nutrient shifts

This study shows that E. coli growth rates on carbon source combinations depend on prior growth conditions, persisting for 15 generations and involving the transcription factor Mlc.

Olfactomedin-4+ neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection.

This study identifies OLFM4+ neutrophils as pathogenic determinants of intestinal epithelial damage during Clostridioides difficile infection using single-cell transcriptomics and pre-clinical models.

Molecular imaging with aquaporin-based reporter genes: quantitative considerations from Monte Carlo diffusion simulations

The paper develops a Monte Carlo model to quantify aquaporin-based imaging signals and demonstrates a method to improve specificity by analyzing time-dependent diffusivity changes.

Combined effects of P25 TiO2 nanoparticles and disposable face mask leachate on microalgae Scenedesmus obliquus: Analysing the effects of heavy metals

This study assesses the combined toxicity of P25 TiO2 nanoparticles and face mask leachates on microalgae Scenedesmus obliquus, revealing harmful effects on cell viability, photosynthesis, and oxidative stress.

Engineering ligand stabilized aquaporin reporters for magnetic resonance imaging

This paper introduces LSAqp1, a genetically encoded MRI reporter that enables drug-gated, background-free, and multiplex imaging of gene expression in living organisms.

A semiconductor 96-microplate platform for real-time impedance-based high-throughput screening

This paper introduces a semiconductor microplate platform for real-time impedance-based high-throughput screening, demonstrating its ability to profile compound mechanisms of action across diverse cell types.

Similar enzymatic functions in distinct bioluminescence systems: Evolutionary recruitment of sulfotransferases in ostracod light organs

The paper shows sulfotransferases in ostracod light organs independently evolved to sulfonate luciferin, highlighting convergent evolution of similar enzymatic functions across distantly related species.

Increase in primary cilia number and length upon VDAC1 depletion contributes to attenuated proliferation of cancer cells

This study shows that VDAC1 depletion increases primary cilia length and number, which inhibits cell proliferation in cancer cells.

Multiparameter stimulation mapping of signaling states in single pediatric immune cells reveals heightened tonic activation during puberty

The paper introduces HDStIM, an unsupervised method to analyze single-cell stimulation responses, revealing increased tonic activation in immune cells during puberty.

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

This study shows adipocytes reprogram cancer cell glucose metabolism to promote metastasis by increasing lipid synthesis via HIF1 regulation.

Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields

The paper introduces TiGGER, a time-resolved EPR method at high magnetic fields, to study protein mechanical dynamics, finding that light activation causes rapid separation and slow relaxation in AsLOV2.

A genetically engineered phage-based nanomaterial for detecting bacteria with magnetic resonance imaging

This paper develops a genetically engineered phage-based nanomaterial for MRI detection of specific bacteria, demonstrating its ability to distinguish target strains from non-target bacteria and mammalian cells in vivo.

Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers

This study shows that IRSp53 couples actin filaments to the nucleus via membrane curvature during 3D cell migration on 1D fibers, affecting protrusion and contractility.

Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

This study shows that Fibromodulin from non-cancer stem cells promotes glioma tumor growth by activating Notch signaling in endothelial cells through integrin-dependent paracrine signaling.

The energy requirements of ion homeostasis determine the lifespan of starving bacteria

This study identifies ion homeostasis as a key determinant of bacterial lifespan during starvation, showing that reducing its energetic cost extends survival.

γ-TuRCs are required for asymmetric microtubule nucleation from the somatic Golgi of Drosophila neurons

This study shows that γ-TuRCs are essential for directional microtubule nucleation from the Golgi in Drosophila neurons, supporting a model of asymmetric microtubule growth and guidance.

Topological morphogenesis of neuroepithelial organoids

This study shows that trans and cis epithelial fusion regulate tissue topology and shape in neuroepithelial organoids, and identifies a pharmacologically accessible pathway to control organoid topology.

Evolutionary flexibility in routes to mat formation by Pseudomonas

This study compares mat formation mechanisms in three Pseudomonas strains, showing different exopolysaccharides and genetic routes for mat formation.