J. Kim

A dual-color miniature endoscope for calcium imaging in behaving mice

This paper introduces a dual-color miniature endoscope for simultaneous calcium imaging of two neuronal populations in behaving mice, revealing direction-dependent activity patterns in striatal neurons.

The Extracellular Matrix Regulates Invasion in Fusion-Negative Rhabdomyosarcoma via YAP-PIEZO1 Signaling Axis

This study identifies a YAP-PIEZO1 signaling axis that links extracellular matrix density to invasion in fusion-negative rhabdomyosarcoma, with therapeutic implications.

The effect of the size of gold nanoparticle contrast agents on CT imaging of the gastrointestinal tract and inflammatory bowel disease

This paper investigates how the size of gold nanoparticle contrast agents affects CT imaging of the gastrointestinal tract in ulcerative colitis.

Inhibiting monocyte migration reduces arterial thrombosis and facilitates thrombolysis

This study shows that inhibiting monocyte migration via CCR2 deficiency reduces arterial thrombosis and improves thrombolysis in mice.

The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis

The paper shows that ATG8a turnover via the Arg/N-degron pathway regulates autophagy and thermotolerance in Arabidopsis during heat stress.

Impacts of Antiretroviral Therapy on the Oral Microbiome and Periodontal Health of Feline Immunodeficiency Virus Positive Cats

This study examines how antiretroviral therapy affects oral health and microbiome in FIV-infected cats, finding reduced gum inflammation and altered bacterial communities in treated animals.

The Staphylococcus aureus small non-coding RNA IsrR regulates TCA cycle activity and virulence

This study shows that the small non-coding RNA IsrR in S. aureus regulates TCA cycle activity and virulence by controlling acnA expression and Fe uptake.

Label-Free Melanoma Phenotype Classification Using Artificial Intelligence-Based Morphological Profiling

This paper develops an AI-based classifier to classify melanoma cell phenotypes using morphology, validated by scRNA-Seq, showing morphology correlates with phenotypic states.

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

Role of Phage-Antibiotic Combinations in Reducing ESBL-Producing and Carbapenem-Resistant Escherichia coli

This study isolates and characterizes two phages effective against ESBL-producing E. coli and CREC, showing enhanced lysis and survival rates when combined with antibiotics.

An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose

The paper introduces an implantable device that autonomously detects and treats opioid overdose, improving survival rates by delivering naloxone and alerting first responders.

CRISPR-Cas9/Cas12a Systems for efficient genome editing and large genomic fragment deletions in Aspergillus niger

This paper compares CRISPR-Cas9 and Cas12a systems for genome editing and large fragment deletions in Aspergillus niger, showing Cas12a's higher efficiency with single gRNA and both systems achieving 100% efficiency with two gRNAs.

Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation

This study uses mechanical oscillation to enhance endosomal escape of mRNA delivered by lipid nanoparticles, improving transfection efficiency without harming cell viability or organelle integrity.

Bred for affection: The canine anterior ectosylvian gyrus responds selectively to social reinforcement

The paper implants a neuromodulation platform in a beagle to study brain activity, finding the anterior ectosylvian gyrus responds selectively to social reinforcement, suggesting speech understanding may evolve from social brain structures.

Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

A Patient-Specific Morphoelastic Growth Model of Aortic Dissection Evolution

This paper develops a patient-specific morphoelastic growth model to predict aortic dissection progression using CT scans and finite element analysis.

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

Parallel evolution of X chromosome-specific SMC complexes in two nematode lineages

This study shows that X chromosome dosage compensation mechanisms evolved independently in two nematode lineages through parallel evolution of SMC complexes.

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

Self-assembly of microstructured protein coatings with programmable functionality for fluorescent biosensors

This paper develops a genetically programmable protein coating platform for a smartphone-based fluorescent biosensor to measure calcium concentrations and detect hypercalcemia.

SCO-pH: Microfluidic dynamic phenotyping platform for high-throughput screening of single cell acidification

SCO-pH enables high-throughput single-cell acidification analysis by compartmentalizing cells in microfluidic droplets and measuring extracellular pH changes to distinguish metabolic states.

Task-Relevant Stimulus Design Improves P300-Based Brain-Computer Interfaces

This paper introduces a task-relevant dynamic stimulus design for P300-based BCIs, achieving high accuracy and information transfer rates with reduced calibration needs.

Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by 64Cu-CTS PET Imaging

This study shows that 64Cu-CTS PET detects hypoxia in hypertrophic mouse hearts independent of perfusion, linking it to structural changes and metabolic shifts.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice

This study shows that β-glucan-induced trained immunity in mice enhances antibody levels after vaccination by improving antigen presentation and T-cell responses.

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

Presynaptic Rac1 in the hippocampus selectively regulates working memory

This study shows that presynaptic Rac1 signaling selectively regulates spatial working memory, with distinct effects on synaptic vesicles and morphology compared to postsynaptic Rac1 inhibition.

Redirecting DNA repair for efficient CRISPR-Cas-based gene targeting in tomato

This study improves CRISPR-Cas gene targeting efficiency in tomato by suppressing nonhomologous end-joining and enhancing homologous recombination.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.