Membrane insertion mechanism of the caveolae coat protein Cavin1
K.-c. Liu, H. Pace, E. Larsson, S. Hossain, A. Kabedev, A. Shukla, V. Jerschabek, J. Mohan, C. A. S. Bergstrom, M. Bally, C. Schwieger, M. Hubert, R. Lundmark
This study reveals how Cavin1 inserts into membranes through PI(4,5)P2-dependent adsorption and helix insertion, facilitated by flanking regions and co-assembly with Caveolin1.
bioRxiv · Mar 23, 2021Biochemistry