E. Larsson

Lipid packing contributes to the confinement of caveolae to the plasma membrane

This study shows that lipid packing, particularly cholesterol, influences caveolae stability and dynamics in the plasma membrane.

Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

This study shows that inhibiting mitochondrial transcription with IMT sensitizes acute myeloid leukemia cells to BCL-2 inhibition, enhancing apoptosis and survival in mouse models.

Dynamin2 stabilizes plasma membrane-connected caveolae by restraining fission

This study uses live-cell microscopy to show that Dyn2 stabilizes caveolae by preventing their fission, independent of its GTPase activity or EHD2.

Membrane insertion mechanism of the caveolae coat protein Cavin1

This study reveals how Cavin1 inserts into membranes through PI(4,5)P2-dependent adsorption and helix insertion, facilitated by flanking regions and co-assembly with Caveolin1.

Lipid accumulation promotes scission of caveolae

The paper shows that cholesterol and glycosphingolipids accumulate in caveolae, reducing their neck diameter and promoting scission from the cell surface, counteracted by EHD2.

Molecular profiling of driver events and tumor-infiltrating lymphocytes in metastatic uveal melanoma

This study profiles genomic and transcriptomic features of metastatic uveal melanoma, identifying BAP1 inactivation and immune checkpoint receptor expression in tumor-infiltrating lymphocytes.

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

This study shows that EHD2 restricts caveolar dynamics to regulate lipid uptake, with loss of EHD2 leading to increased fat accumulation and obesity in mice.

Elevated pyrimidine dimer formation at distinct genomic bases underlie promoter mutation hotspots in UV-exposed cancers

The paper shows that UV-induced mutations in cancer promoters are due to base-specific increases in pyrimidine dimer formation, not inhibited repair.