M. Hubert

Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma

This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

This study characterizes SARS-CoV-2 variants XBB and BA.2.86/JN.1, finding they show increased fitness and antibody evasion while maintaining antiviral sensitivity.

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

Laminin-defined Mechanical Status Modulates Retinal Pigment Epithelium Functionality

This study shows that laminin density in the retinal pigment epithelium basement membrane modulates contractility and phagocytic efficiency, linking mechanical status to visual function.

CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

The paper shows CD4 T cells and neutrophils promote EMT in breast cancer by analyzing murine tumor models and human cohorts.

A Unique Polyfunctional IL-33-responsive ST2⁺ NK cell State Potentiates Antitumor Immunity and Response to Immunotherapy

The paper identifies a unique ST2+ NK cell state that enhances antitumor immunity and response to immunotherapy through IL-33 and IL-12 signaling.

Capturing the mechanosensitivity of cell proliferation in models of epithelium

The paper investigates how cell density and mechanical response influence cell proliferation in model tissues, showing that mechanoresponse and proliferation create an active pressure driving tissue growth.

Morphology as indicator of adaptive changes of model tissues in osmotically and chemically changing environments

The paper investigates how hyperosmotic environments affect 2D epithelial tissue morphology, topology, and homeostasis over time.

Gene signature of circulating platelet-bound neutrophils is associated with poor prognosis in cancer patients

The paper identifies a gene signature in neutrophil-platelet aggregates (NPAs) associated with poor prognosis in cancer patients.

SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation

This study compares syncytia formation by SARS-CoV-2 Alpha, Beta, and Delta variants to D614G, finding enhanced fusogenicity and differential effects of mutations on ACE2 binding and antibody escape.

On the mechanical regulation of epithelial tissue homeostasis

This study shows matrix stiffness changes induce a non-equilibrium transition in epithelial tissues and reveals a complex relationship between cell density and motility.

Membrane insertion mechanism of the caveolae coat protein Cavin1

This study reveals how Cavin1 inserts into membranes through PI(4,5)P2-dependent adsorption and helix insertion, facilitated by flanking regions and co-assembly with Caveolin1.

SARS-CoV-2 surveillance in Norway rats (Rattus norvergicus) from Antwerp sewer system, Belgium

The paper tests Norway rats for SARS-CoV-2 infection and finds no evidence of infection, but highlights issues with serological testing in non-human samples.

Syncytia formation by SARS-CoV-2 infected cells

This study shows SARS-CoV-2 infected cells form syncytia via Spike protein-mediated fusion, regulated by IFITMs and TMPRSS2.

SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance

This study shows SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance, potentially facilitating viral spread to the deeper lung.

Lipid accumulation promotes scission of caveolae

The paper shows that cholesterol and glycosphingolipids accumulate in caveolae, reducing their neck diameter and promoting scission from the cell surface, counteracted by EHD2.