Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus
M. S. Sutton, A. Ellis-Connell, A. J. Balgeman, G. L. Barry, A. M. Weiler, S. J. Hetzel, Y. Zhou, A. Kilby, R. Mason, K. K. Biris, J. R. Mascola, N. Sullivan, M. Roederer, T. C. Friedrich, S. L. O'Connor
This study shows that CD8β+ T cell depletion in SIV-infected macaques does not prevent viral control or protection from challenge, suggesting CD8β+ T cells are not essential for these outcomes.
bioRxiv · Apr 13, 2019Immunology