A. Ellis-Connell

IL-15 superagonist N-803 enhances IFNγ production and alters the trafficking of MAIT cells in SIV+ macaques

This study shows that N-803 increases IFNγ production and alters MAIT cell trafficking in SIV+ macaques.

Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis

This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.

Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus

This study shows that CD8β+ T cell depletion in SIV-infected macaques does not prevent viral control or protection from challenge, suggesting CD8β+ T cells are not essential for these outcomes.

Pre-existing SIV Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques

This study shows that pre-existing SIV infection in macaques increases susceptibility to tuberculosis by impairing immune control of M.tb.

Acute-phase CD4+ T cell responses targeting invariant viral regions are associated with control of live-attenuated simian immunodeficiency virus

This study shows that CD4+ T cell responses targeting invariant viral regions in MCMs without protective MHC alleles correlate with lower viral load during SIV infection.