Cyclic dichalcogenides extend the reach of bioreductive prodrugs to harness the thioredoxin system: applications to seco-duocarmycins
J. G. Felber, A. Kitowski, L. Zeisel, M. S. Maier, C. Heise, J. Thorn-Seshold, O. Thorn-Seshold
This paper introduces a new class of bioreductive prodrugs activated by the thioredoxin system, showing in vivo efficacy against breast and pancreatic cancer.
bioRxiv · Nov 11, 2022Biochemistry