BiochemistrybioRxiv
Cyclic dichalcogenides extend the reach of bioreductive prodrugs to harness the thioredoxin system: applications to seco-duocarmycins
J. G. Felber, A. Kitowski, L. Zeisel…·O. Thorn-Seshold
This paper introduces a new class of bioreductive prodrugs activated by the thioredoxin system, showing in vivo efficacy against breast and pancreatic cancer.
DOI 10.1021/acscentsci.2c01465