Activation of the Integrated Stress Response in drug-tolerant melanoma cells confers vulnerability to mitoribosome-targeting antibiotics.
R. Vendramin, A. Konnova, S. Adnane, S. Cinque, V. Katopodi, Z. Knezevic, P. Karras, E. Demesmaeker, F. M. Bosisio, L. Rizzotto, O. Bechter, J.-C. Marine, E. Leucci
This study shows that activating the Integrated Stress Response in drug-tolerant melanoma cells makes them vulnerable to mitoribosome-targeting antibiotics, offering a new therapeutic strategy.
bioRxiv · Jun 26, 2020Cancer Biology