Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents
S. Kriegeskorte, R. Bott, M. Hampl, A. Korngreen, R. Hausmann, A. Lampert
This study examines how temperature affects sodium channel gating and persistent currents in Nav1.3, Nav1.5, Nav1.6, and Nav1.7, with specific focus on mutations linked to pain disorders.
bioRxiv · Dec 19, 2022Physiology