Human Milk Oligosaccharide 2'-fucosyllactose inhibits ligand binding to C-type lectin DC-SIGN but not to Langerin
R. Mukherjee, V. J. Somovilla, F. Chiodo, S. Bruijns, R. J. Pieters, J. Garssen, Y. van Kooyk, J. v. BERGENHENEGOUWEN, A. Kraneveld
This study shows that 2'-fucosyllactose (2-FL) inhibits DC-SIGN ligand binding but not Langerin, with molecular dynamics revealing structural differences in binding modes.
bioRxiv · Jul 27, 2022Biochemistry