R. Mukherjee

Crude extract of Ruellia tuberosa L. flower induces intracellular ROS, promotes DNA damage and apoptosis in Triple Negative Breast Cancer Cells

This study shows that the methanolic extract of Ruellia tuberosa L. flower induces ROS, causes G0/G1 cell cycle arrest, and promotes apoptosis in TNBC cells without toxicity in mice.

Development of covalent probes to capture Legionella pneumophila effector enzymes

The paper develops covalent probes to target Legionella pneumophila effector enzymes, demonstrating their effectiveness in capturing DupA through in vitro testing and structural analysis.

Prior exposure to malaria decreases SARS-CoV-2 mediated mortality in K18-hACE2 mice without influencing viral load in lungs

This study shows that prior malaria exposure in K18-hACE2 mice reduces SARS-CoV-2 mortality without affecting lung viral load.

Outer membrane proteins in Mycobacterium tuberculosis and its potential role in small molecule permeation

This study identifies outer membrane proteins in Mycobacterium tuberculosis involved in small molecule permeation, with potential applications for improving anti-TB drug efficacy.

ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

The paper investigates how aminoglycoside and fluoroquinolone antibiotics induce cell death in M. smegmatis by increasing TCA cycle flux, ATP production, and ROS, with ATP levels being the primary driver of lethality.

Kinetic Proofreading can Enhance Specificity in a Non-enzymatic DNA Strand Displacement Network

This study introduces a DNA strand displacement-based kinetic proofreading motif that enhances molecular recognition specificity in templated dimerization reactions by consuming DNA-based fuel.

Information propagation through enzyme-free catalytic templating of DNA dimerization with weak product inhibition

This study presents an enzyme-free DNA templating system that produces sequence-specific dimers with weak product inhibition, demonstrating a design principle for information propagation through molecular templating.

Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis

This study shows that serine ubiquitination of p62 by Legionella pneumophila SidE effectors inhibits Nrf2 signaling, altering redox homeostasis and host metabolism during infection.

Vascular Smooth Muscle Cell Mechanotransduction Through Serum and Glucocorticoid Inducible Kinase-1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension

This study shows that SGK-1 in vascular smooth muscle cells promotes IL-6 and macrophage accumulation in hypertension via mechanotransduction and AngII signaling.

TBC1D15 potentiates lysosomal regeneration from damaged membranes

The paper identifies TBC1D15 as a key regulator of lysosomal regeneration from damaged membranes through a pathway involving LIMP2, ATG8, and ALR components.

Human Milk Oligosaccharide 2'-fucosyllactose inhibits ligand binding to C-type lectin DC-SIGN but not to Langerin

This study shows that 2'-fucosyllactose (2-FL) inhibits DC-SIGN ligand binding but not Langerin, with molecular dynamics revealing structural differences in binding modes.

Immunomodulatory effect of mycobacterial outer membrane vesicles coated nanoparticles

This study develops OMV-AuNP as a stabilized TB vaccine candidate showing enhanced immune activation through TLR2 and TLR4.

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

The paper identifies a c-Rel and USP1 dependent pathway that regulates CHK1 inhibitor resistance in lymphoma cells.

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

This study characterizes Nsp3 protease activity from SARS-CoV-2 and identifies nanobodies that inhibit PLpro with nanomolar affinity.

N-myristoyltransferase: Tracing Steps Backwards to Find a Way Forward

This study investigates the evolutionary history and functional regulation of N-myristoyltransferase (NMT) in vertebrates, identifying two NMT genes and potential nuclear localization mechanisms.

Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection

This study shows that Legionella's SdeA effector causes Golgi disruption via serine ubiquitination of GRASP55 and GRASP65, affecting the secretory pathway and cytokine release.

Quantifying the dynamics of hematopoiesis by in vivo IdU pulse-chase, mass cytometry and mathematical modeling

The paper develops a method combining IdU pulse-chase, mass cytometry, and mathematical modeling to quantify hematopoietic differentiation dynamics in mice.

DNA damage dependent hypomethylation regulates the pro-angiogenic LncRNA MEG9

The paper shows DNA damage reduces DNMTs in endothelial cells, leading to increased MEG9 expression, which protects cells from DNA damage-induced death and promotes angiogenesis.

3D micro-environment regulates NF-κβ dependent adhesion to induce monocyte differentiation

This paper shows that 3D gel-like micro-environments induce monocyte differentiation through adhesion-MAPK-NF-κβ feedback, challenging the idea that adhesion is a result of differentiation.