Invariant chain with an AP3 interacting sorting signal is sorted to late endosomal compartments and may improve MHC class I loading and presentation.
A. Kucera, N. B. Pati, E. M. Inderberg, T. F. Gregers, S. Walchli, O. Bakke
This study modifies the invariant chain (Ii) to enhance MHC class I antigen presentation by replacing sorting signals and adding a peptide epitope, improving T-cell activation.
bioRxiv · May 13, 2020 · PreprintImmunology