Caveolae mediated endocytosis of VLDL particles in macrophages requires NPC1 and STARD3 for further lysosomal processing
L. Deng, F. Vrieling, R. Stienstra, G. Hooiveld, A. L. Feitsma, S. Kersten
The paper investigates how macrophages process VLDL-triglycerides, showing caveolae-mediated endocytosis and the roles of LPL, lysosomal acid lipase, Stard3, and NPC1 in lipid uptake, hydrolysis, and efflux.
bioRxiv · Dec 16, 2021 · PreprintCell Biology