Author

S. Kersten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Organism:human· 3 Organism:mouse· 3 Organism:Arabidopsis· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

D. Weigel· 3 shared R. Stienstra· 3 shared D. S. Lundberg· 2 shared F. Vrieling· 2 shared J. Regalado· 2 shared J. W. Borst· 2 shared M. Neumann· 2 shared M. van Weeghel· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersEvolutionary Biology

D. Weigel

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Author profile →

8 papers

Recent·Most cited

Multi-omic profiling of pathogen-stimulated primary immune cells

R. Salz, E. E. Vorsteveld, C. I. van der Made, S. Kersten, M. Stemerdink, T. Hsieh, M. Mhlanga, M. Netea, P.-J. Volders, A. Hoischen, P. A. C. 't Hoen

The paper uses long-read sequencing to profile immune cells stimulated by pathogens, identifying novel transcripts and isoforms that reveal new insights into immune response mechanisms.

bioRxiv · Sep 13, 2023Immunology

In-depth immunometabolic profiling by measuring cellular protein translation inhibition via bioorthogonal noncanonical amino acid tagging (CENCAT)

F. Vrieling, H. J. P. van der Zande, B. Naus, L. Smeehuijzen, B. J. Ignacio, K. M. Bonger, J. van den Bossche, S. Kersten, R. Stienstra

The paper introduces CENCAT, a method to measure protein synthesis inhibition in immune cells using noncanonical amino acid tagging, showing its utility in analyzing metabolic responses in complex samples and tissue-resident immune cells.

bioRxiv · Aug 3, 2023 · PreprintImmunology

Caveolae mediated endocytosis of VLDL particles in macrophages requires NPC1 and STARD3 for further lysosomal processing

L. Deng, F. Vrieling, R. Stienstra, G. Hooiveld, A. L. Feitsma, S. Kersten

The paper investigates how macrophages process VLDL-triglycerides, showing caveolae-mediated endocytosis and the roles of LPL, lysosomal acid lipase, Stard3, and NPC1 in lipid uptake, hydrolysis, and efflux.

bioRxiv · Dec 16, 2021 · PreprintCell Biology

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

S. Kersten, J. Chang, C. D. Huber, Y. Voichek, C. Lanz, T. Hagmaier, P. Lang, U. Lutz, I. Hirschberg, J. Lerchl, A. Porri, Y. Van de Peer, K. Schmid, D. Weigel, F. A. Rabanal

This study investigates the genetic basis of herbicide resistance in blackgrass, finding that target-site resistance primarily arises from standing genetic variation rather than de novo mutations.

bioRxiv · Dec 14, 2021Evolutionary Biology

The relationship between microbial population size and disease in the Arabidopsis thaliana phyllosphere

T. L. Karasov, M. Neumann, A. Duque-Jaramillo, S. Kersten, I. Bezrukov, B. Schroeppel, E. Symeonidi, D. S. Lundberg, J. Regalado, G. Shirsekar, J. Bergelson, D. Weigel

The paper assesses microbial load and composition in Arabidopsis thaliana phyllosphere using shotgun metagenomics, finding high microbial loads correlate with pathogen proliferation and reduced diversity.

bioRxiv · Apr 8, 2020 · PreprintPlant Biology

Hypoxia-inducible lipid droplet-associated interacts with DGAT1 and promotes lipid storage in hepatocytes

M. de la Rosa Rodriguez, A. Gemmink, M. van Weeghel, M. L. Aoun, R. Singh, J. W. Borst, S. Kersten, C. Warnecke

This study identifies HILPDA as a protein that interacts with DGAT1 and enhances lipid storage in hepatocytes by promoting triglyceride synthesis.

bioRxiv · Feb 26, 2020Biochemistry

HILPDA uncouples lipid storage in adipose tissue macrophages from inflammation and metabolic dysregulation

X. A. M. H. van Dierendonck, M. A. de la Rosa Rodriguez, A. Georgiadi, F. Mattijssen, W. Dijk, M. van Weeghel, R. Singh, J. W. Borst, R. Stienstra, S. Kersten

This study shows that HILPDA deficiency reduces lipid storage in adipose tissue macrophages without affecting inflammation or metabolic issues in obese mice.

bioRxiv · Mar 5, 2019Physiology

Stability of association between Arabidopsis thaliana and Pseudomonas pathogens over evolutionary time scales

T. L. Karasov, J. Almario, C. Friedemann, W. Ding, M. Giolai, D. Heavens, S. Kersten, D. S. Lundberg, M. Neumann, J. Regalado, R. A. Neher, E. Kemen, D. Weigel

The paper surveys Pseudomonas in Arabidopsis thaliana over multiple years and sites, finding that pathogenic sublineages coexist without a single dominant strain overtaking populations.

bioRxiv · Jan 30, 2018Microbiology