RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation
N. Zhou, A. Gutierrez Uzquiza, X. Y. Zheng, D. Vogl, A. L. Garfall, L. Bernabei, A. Saraf, L. Florens, M. P. Washburn, A. Illendula, J. H. Bushweller, L. Busino
This study identifies RUNX1 and RUNX3 as proteins that protect IKZF1 and IKZF3 from lenalidomide-induced degradation, thereby reducing the effectiveness of lenalidomide in multiple myeloma.
bioRxiv · Sep 20, 2018Cancer Biology