Cancer BiologybioRxiv
p53 restoration in small cell lung cancer identifies a latent Cyclophilin-dependent necrosis mechanism
J. Acosta, Q. Li, N. F. Freebrug…·D. M. Feldser
This study shows that p53 restoration in SCLC can induce necrosis via cyclophilin-dependent mechanisms, revealing subtype-specific responses and potential therapeutic targets.
DOI 10.1038/s41467-023-40161-9