Structure-guided aminoacylation and assembly of chimeric RNAs
A. Radakovic, A. Lewicka, M. Todisco, H. R. M. Aitken, Z. Weiss, S. Kim, A. Bannan, J. A. Piccirilli, J. W. Szostak
The paper shows that specific RNA sequences can be nonenzymatically aminoacylated and ligated to form amino acid-bridged stem-loop RNAs, with structural and functional similarities to modern tRNA.
bioRxiv · Mar 2, 2024 · PreprintBiochemistry