S. Kim

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Hidden route of protein damage through confined oxygen gas

The paper identifies a hidden oxidative damage pathway in proteins through O2 confinement and photoexcitation, bypassing antioxidant defenses.

Robust Binding Capability and Occasional Gene Loss of Telomere-Binding Proteins Underlying Telomere Evolution in Nematoda

The paper investigates how telomere repeats evolved in nematodes despite the specificity of telomere-binding proteins, finding that protein conservation and binding affinity correlate with the emergence of novel telomeric motifs.

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

Intervening to preserve function in ischemic cardiomyopathy with a porous hydrogel and extracellular matrix composite in a rat myocardial infarction model

This study evaluates a hydrogel with porosity and extracellular matrix digest in a rat myocardial infarction model, showing improved cardiac function and neovascularization compared to other hydrogels and PBS.

Role of Phage-Antibiotic Combinations in Reducing ESBL-Producing and Carbapenem-Resistant Escherichia coli

This study isolates and characterizes two phages effective against ESBL-producing E. coli and CREC, showing enhanced lysis and survival rates when combined with antibiotics.

Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model of Caenorhabditis elegans

The paper investigates wavenumber-dependent transmission of subthreshold oscillations in a C. elegans electrical synapse network model, identifying transmission patterns and thresholds.

Genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumor

This study compares genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumors in SCLC patients, finding cfDNA reflects tumor mutations, identifies resistance mechanisms, and tracks tumor evolution.

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

This study shows that BPTMC exposure in C. elegans causes mitochondrial dysfunction, reduced lifespan, and healthspan, raising concerns about its safety as a BPA substitute.

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer

This study investigates the immune microenvironment of ING4-deficient breast cancer, showing a suppressive immune environment linked to poor patient survival.

Energy partitioning in the cell cortex

The paper measures energy partitioning between chemical and mechanical subsystems in the cell cortex and finds that energy distribution changes with Rho GTPase pathway manipulation.

HER4 is a high affinity dimerization partner for all EGFR/HER/ErbB-family proteins

This study uses PIE-FCCS to show HER4 directly interacts with all HER family members in live cells, even without ligands, suggesting HER4 is a preferred dimerization partner.

In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

This study uses single nucleus RNA-Seq to show increased adipogenesis and IGF-1R pathway alterations in TED orbital fat, suggesting linsitinib as a potential therapeutic.

Re-defining how mRNA degradation is coordinated with transcription and translation in bacteria

This study investigates how mRNA degradation is coordinated with transcription and translation in bacteria, finding that RNase E localization and translation affect mRNA stability in Escherichia coli and other species.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Functional ultrasound (fUS) imaging of displacement-guided focused ultrasound (FUS) neuromodulation in mice

This study uses functional ultrasound imaging to monitor brain tissue displacement and hemodynamic responses during focused ultrasound neuromodulation in mice, showing a correlation between displacement and cerebral blood volume changes.

An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment

This paper introduces mLumiOpto, a mitochondrial-targeted gene therapy that disrupts cancer cell mitochondria using light-activated proteins, showing efficacy in reducing tumor burden in mouse models.

Transcranial Functional Ultrasound Imaging Detects Focused Ultrasound Neuromodulation Induced Hemodynamic Changes In Vivo

This study uses transcranial functional ultrasound imaging to detect hemodynamic changes induced by focused ultrasound neuromodulation in mice.

Structure-guided aminoacylation and assembly of chimeric RNAs

The paper shows that specific RNA sequences can be nonenzymatically aminoacylated and ligated to form amino acid-bridged stem-loop RNAs, with structural and functional similarities to modern tRNA.

A novel truncated CHAP modular endolysin, CHAPSAP26-161, that lyses Staphylococcus aureus, Acinetobacter baumannii, and Clostridioides difficile

This paper describes a truncated endolysin, CHAPSAP26-161, derived from the CHAP domain of LysSAP26, which shows enhanced antibacterial activity and stability against multiple antibiotic-resistant bacteria, including in vivo efficacy against Acinetobacter baumannii.

Modulation of stress granule dynamics by phosphorylation and ubiquitination in plants

This study identifies phosphorylation and ubiquitination as key regulators of TZF1 stress granule assembly in Arabidopsis.

Leaf abaxial and adaxial surfaces differentially affect plant-fungal pathogen interactions

The paper investigates how Botrytis cinerea interacts with abaxial and adaxial leaf surfaces across multiple plant species, finding that abaxial surfaces are more susceptible and linking this to defense signaling and compound production.

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.

Thermal Tolerance Plasticity and Dynamics of Thermal Tolerance in Eublepharis macularius: Implications for Future Climate-Driven Heat Stress

This study examines thermal tolerance and plasticity in the crepuscular gecko Eublepharis macularius, finding that plasticity is independent of basal tolerance, peaks after 6 hours, and is negatively related to body mass.

Rapid and label-free exosome analysis by surface-enhanced Raman spectroscopy using silver nanoparticle substrate based on selective laser ablation and melting of silver nanowire

This paper presents a rapid, label-free method for detecting breast cancer-derived exosomes using SERS with a silver nanoparticle substrate fabricated via laser ablation and melting.

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.