Evolution of the substrate specificity of an RNA ligase ribozyme from phosphorimidazole- to triphosphate-activation
S. DasGupta, Z. Weiss, C. Nisler, J. W. Szostak
This study shows that an RNA ligase ribozyme evolved from using phosphorimidazole-activated substrates to triphosphate-activated substrates through neutral mutations, leading to a new structure and function.
bioRxiv · Apr 11, 2024Biochemistry