Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes
Y. Zhang, R. L. Belote, M. A. Urquijo, M. M. Hansen, M. Hejna, T. E. Moustafa, T. Liu, D. Lange, F. Vand-Rajabpour, M. Chang, B. K. Lohman, C. Stubben, X. Zhang, L. S. Weinberger, M. W. VanBrocklin, , R. L. Judson-Torres
This study identifies bidirectional interconversion between tumorigenic and drug-tolerant melanoma cell states through BRN2 expression, revealing distinct molecular programs and therapeutic implications.
bioRxiv · Aug 26, 2020 · PreprintCancer Biology