T. Liu

A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer

This study identifies TROP2 as a regulator of tight junction-mediated immune exclusion in TNBC, showing that targeting TROP2 enhances anti-PD1 therapy response.

3D printed bioelectronic scaffolds with soft tissue-like stiffness

This study develops 3D printed PEDOT:PSS hydrogel scaffolds with soft tissue-like stiffness to support cell viability and function in bioelectronic applications.

A Comprehensive Framework for Spatio-Temporal Analysis of DNA Damage Foci in Tumor Spheroids.

This paper develops a semi-automated image analysis framework to quantify spatiotemporal DNA damage foci in live tumor spheroids using live imaging and fluorescent sensors.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

Specialized Pericyte Subtypes in the Pulmonary Capillary

The paper identifies two specialized pericyte subtypes in pulmonary capillaries using Higd1b as a marker and shows their distinct functions and responses to hypoxia.

Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level

This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.

Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin

This study shows that natural variation in neuraminidase activity affects the evolutionary potential of hemagglutinin in seasonal H1N1 influenza viruses.

Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathways

The paper uses Hi-C profiling in breast tissues to reveal 3D chromatin-regulated tumor heterogeneity and identifies CA2 as a driver of tamoxifen resistance through enhancer-promoter looping.

Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis

The paper identifies cellular and neurochemical signatures associated with cerebral blood flow alterations in schizophrenia and clinical high-risk states using combined neuroimaging and transcriptomic data.

The discovery of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica using deep learning pipeline

The paper develops a deep learning pipeline to identify antimicrobial peptides from the gut microbiome of Blattella germanica, finding two AMPs with low toxicity and antimicrobial activity.

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.

Gentle rhodamines for live-cell fluorescence microscopy

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

Dissecting reprogramming heterogeneity at single-cell resolution using scTF-seq

The paper introduces scTF-seq, a method to study TF dose-dependent reprogramming in mouse MSCs, revealing heterogeneity in cell fate and TF sensitivity.

Temporal variability in host availability alters the outcome of competition between two parasitoid species

This study shows that temporal variability in host availability affects competition outcomes between two parasitoid species based on their reproductive strategies.

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

Effect of eye globe and optic nerve morphologies on gaze-induced optic nerve head deformations

This study uses finite element modeling to show that eye morphology and tissue stiffness significantly affect optic nerve head deformations during gaze shifts.

Wearable Disposable Electrotherapy

This paper introduces a disposable electrotherapy platform that eliminates electronic components and uses scalable manufacturing, enabling single-use applications for various medical and therapeutic purposes.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

Utility of T1 mapping and T2 mapping for non-invasive assessment of liver fibrosis: preclinical results

This study evaluates T1 and T2 mapping for assessing liver fibrosis in mice, finding they correlate with fibrosis stages and collagen/protein markers.

ESR1 fusion proteins invoke breast cancer subtype-dependent enrichment of ligand independent pro-oncogenic signatures and phenotypes

This study shows ER fusion proteins in breast cancer cell lines drive ligand-independent pro-oncogenic pathways, with subtype- and fusion-specific effects.

Reconciling ASPP-p53 Binding Mode Discrepancies through an Ensemble Binding Framework that Bridges Crystallography and NMR Data

This study reconciles discrepancies in ASPP-p53 binding modes by showing that an ensemble of simulated complexes better aligns with experimental data than single crystal structures.

WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

A mathematical model for velocity-selective arterial spin labeling

The paper develops a mathematical model for velocity-selective arterial spin labeling (VSASL) to analyze key concepts and predict performance characteristics.

3D Printed Ti3C2Tx MXene/PCL Scaffolds for Guided Neuronal Growth and Photothermal Stimulation

This paper develops 3D printed scaffolds with MXene coatings to guide neuronal growth and enable photothermal stimulation for neural circuit engineering.

Cell-extrinsic effects of Irf2 on cDC2 development

The paper investigates the cell-extrinsic role of IRF2 in cDC2 development and shows that IFN signaling is critical for this process.