X. Zhang

This study shows that L-selectin shedding regulates neutrophil mobilization after heart attack but does not affect heart damage or remodeling.

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

This paper develops a probiotic system for ulcerative colitis that enhances probiotic survival and colon targeting, modulates gut microbiota and immune responses, and provides a mathematical model for release dynamics.

This study uses simulations and experiments to show that diblock polypeptides form interfacial environments due to hydrophilic-hydrophobic residue distribution, affecting condensate stability and hydrogen bonding.

The paper introduces AggreBots, a platform for creating designer motility patterns in multicellular tissues by spatially controlling the aggregation of epithelial spheroids, achieving greater motility than traditional CiliaBots.

This study identifies BRAT1 as a key driver of glioblastoma growth and invasion, showing that its inhibition with CurD reduces tumor migration and enhances radiation sensitivity.

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

The paper shows IL-22/IL-22RA1 promotes fibroblast proliferation and fibrosis via STAT3 signaling in glaucoma patients.

This study analyzes phenotypic diversity in 43 Sect. Paeonia peony varieties using PCA, cluster analysis, and comprehensive evaluation to identify key traits influencing diversity and breeding potential.

This study shows that Snf1/AMPK inhibits misfolded protein import into mitochondria and promotes mitochondrial biogenesis under glucose starvation, protecting mitochondrial fitness in yeast and human cells.

The paper develops a deep learning framework to map genotypes to fitness, applies it to predict viral mutations and immune escape, and computes the genotype-fitness landscape for SARS-CoV-2.

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

This study investigates how Ribisin A protects PC12 cells from H2O2-induced injury by enhancing antioxidant activity, reducing inflammation, and modulating the ERK/CREB signaling pathway.

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

This study identifies MxROP1 as a regulator of Fe deficiency responses in apple rootstock by interacting with ZR3.1 and modulating its stability and interaction with MxbHLH39.

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

The paper develops a cell type-specific multiomics pipeline to analyze guard cells and mesophyll cells, revealing a kinase cascade involved in ABA-induced stomatal closure.

The study identifies SARS-CoV-2 Mpro mutations associated with nirmatrelvir resistance from clinical isolates.