Author

A. Linder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

K. Eyer· 2 shared K. Portmann· 2 shared A. Augustoni· 1 shared A. Bakochi· 1 shared A. Janjic· 1 shared A. Leunig· 1 shared A. Naegeli· 1 shared C. A. Q. Karlsson· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersImmunology

K. Eyer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis

O. T. M. Bucheli, D. Rodrigues, K. Portmann, A. Linder, M. Thoma, C. Halin, K. Eyer

The paper correlates high lactate secretion in B cells with stress and increased apoptosis, using single-cell transcriptomics and metabolic flux analysis in mice.

bioRxiv · Sep 1, 2023Immunology

Stimulation-induced cytokine polyfunctionality as a dynamic concept

K. Portmann, A. Linder, K. Eyer

This study investigates cytokine polyfunctionality dynamics in PBMCs using a single-cell microfluidic platform, revealing distinct secretion patterns and reduced polyfunctionality with prolonged stimulation.

bioRxiv · Jul 18, 2023Immunology

Wikipedia as a tool for contemporary history of science: A case study on CRISPR

O. Benjakob, O. Guley, J.-M. Sevin, L. Blondel, A. Augustoni, M. Collet, L. Jouveshomme, R. Amit, A. Linder, R. Aviram

The paper uses Wikipedia to study the historical development of CRISPR, showing its transition from scientific discovery to biotech revolution and demonstrating a method applicable to other fields.

bioRxiv · Nov 25, 2022Scientific Communication & Education

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

K. Pekayvaz, A. Leunig, R. Kaiser, S. Brambs, M. Joppich, A. Janjic, O. Popp, V. Polewka, L. E. Wange, C. Gold, M. Kirchner, M. Muenchhoff, J. C. Hellmuth, C. Scherer, T. Eser, , L. Nicolai

This study identifies an early interferon-stimulated gene (ISG) upregulation as a protective immune signature in non-pneumonic SARS-CoV-2 infection, preventing progression to pneumonia.

bioRxiv · Feb 3, 2021Immunology

Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis.

A. Bakochi, T. Mohanty, P. T. Pyl, L. Malmstroem, A. Linder, J. Malmstroem

The paper constructs CSF proteome maps to identify pathogen-specific host response patterns in meningitis, revealing distinct protein signatures for bacterial and viral types.

bioRxiv · Sep 18, 2020Microbiology

Sweet revenge - Streptococcus pyogenes showcases first example of immune evasion through specific IgG glycan hydrolysis

A. Naegeli, E. Bratanis, C. Karlsson, O. Shannon, R. Kalluru, A. Linder, J. Malmström, M. Collin

This study identifies EndoS as a mechanism by which Streptococcus pyogenes evades the immune system by hydrolyzing IgG glycans, impairing antibody effector functions during infection.

bioRxiv · Mar 7, 2019Microbiology

Streptococcus pyogenes infection and the human proteome with a special focus on the IgG-cleaving enzyme IdeS

C. A. Q. Karlsson, S. Järnum, L. Winstedt, C. Kjellman, L. Björck, A. Linder, J. A. Malmström

This study investigates how Streptococcus pyogenes modifies the human proteome, focusing on IgG cleavage by IdeS, and identifies clinical opportunities for pathogen detection.

bioRxiv · Dec 2, 2017Microbiology