O. Popp

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

Identification of tumor-specific MHC ligands through improved biochemical isolation and incorporation of machine learning

This paper improves the isolation of tumor-specific MHC ligands through hydrophobicity and post-translational modification considerations and introduces a machine learning model for predicting MHC ligand presentation.

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

The paper generates kidney organoids and genetic mouse models with altered stem cell signaling, finding CKD symptoms but no tumors.

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts

This study identifies two tryptophan-rich proteins essential for Plasmodium berghei blood-stage growth and sequestration of infected red blood cells.

Implementing solid-phase-enhanced sample preparation for Co-Immunoprecipitation with Mass Spectrometry for C. elegans

The paper optimizes CoIP-MS for C. elegans by integrating SP3 sample preparation, demonstrating high accuracy and robustness in detecting protein-protein interactions.

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

This study identifies an early interferon-stimulated gene (ISG) upregulation as a protective immune signature in non-pneumonic SARS-CoV-2 infection, preventing progression to pneumonia.

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

This paper shows that a single amino acid swap at position 72 can switch the substrate specificity of Rub1/NEDD8 and ubiquitin, revealing their distinct roles in cellular modification pathways.

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer

This study shows YAP and β-catenin cooperate in basal breast cancer to drive CSCs, with targeting this complex as a potential therapeutic strategy.

Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy

This study identifies PKA-mediated phosphorylation of ATG16L1 as a mechanism to limit autophagy and regulate angiogenesis in endothelial cells.

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.