ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
M. Veronese, S. Kallabis, A. Kaczmarek, L. Robers, S. Schumacher, A. Das, A. Lofrano, S. Brodesser, S. Müller, K. Hofmann, M. Krüger, E. I. Rugarli
This study identifies ERLIN1/2 scaffolds that mediate TMUB1-RNF170 interactions, regulate cholesterol esterification, and maintain ER cholesterol levels to control Golgi morphology and the secretory pathway.
bioRxiv · Jan 17, 2024Cell Biology