A. Das

EMMPRIN confers metabolic advantage for monocytes and macrophages to promote disease in a model of multiple sclerosis

This study shows that EMMPRIN promotes pro-inflammatory metabolism in monocytes/macrophages, worsening multiple sclerosis, and its deletion reduces disease severity.

Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis

Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase

This study identifies the structural basis for the dual function of SrtC2 in pilus assembly by showing how its extended lid modulates polymerization and anchoring activities.

DNA targeting by compact Cas9d and its resurrected ancestor

This study reports cryo-EM structures of Cas9d, revealing its DNA targeting mechanism and demonstrating a compact variant with robust nuclease activity in mammalian cells.

Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma

This study shows that peroxidasin (PXDN) promotes invasion in metastatic melanoma by supporting a mesenchymal-like transcriptional phenotype, as demonstrated through transcriptomic and proteomic analyses.

Harnessing Transformers to Generate Protein Sequences Prone to Liquid Liquid Phase Separation

This paper uses GPT-based models to generate protein sequences prone to liquid-liquid phase separation and validates their ability to form phase-separated states.

Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway

This study identifies ERLIN1/2 scaffolds that mediate TMUB1-RNF170 interactions, regulate cholesterol esterification, and maintain ER cholesterol levels to control Golgi morphology and the secretory pathway.

Clustered Regularly Interspaced Short Palindromic Repeats-Cas system regulates Salmonella virulence

This study shows that the CRISPR-Cas system in Salmonella enhances virulence by regulating virulence factor expression.

Haplo-pheno association for OsNRT1.1 paralog in rice reveals superior haplogroup with high nitrate uptake efficiency

The paper identifies superior and inferior haplotypes of OsNRT1.1 paralogs in rice associated with nitrate uptake efficiency through haplo-pheno association analysis.

Evolution of tandem repeats in putative CSP to enhance its function: A recent and exclusive event in Plasmodium vivax in India

The paper identifies genetic polymorphism and natural selection in PvpuCSP of Plasmodium vivax, highlighting its role in adaptation and diversity.

From the Wild to the City: How Domestication and Urbanization Reshape Animal Gut Microbiome

This review examines how domestication and urbanization alter gut microbiomes in animals, comparing their effects on microbial communities and ecological implications.

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy

This study shows that metabolic reprogramming in the neurovascular niche promotes regenerative angiogenesis in proliferative retinopathy by shifting metabolism from fatty acid oxidation to glycolysis.

Myeloid Drp1 Deficiency Limits Revascularization in Ischemic Muscles via Inflammatory Macrophage Polarization and Metabolic Reprograming

This study shows that myeloid Drp1 deficiency impairs revascularization in ischemic muscle by promoting pro-inflammatory macrophage polarization and metabolic reprogramming.

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

Assessing variation in Citrus limon "Assam lemon": morphological, seed availability pattern, and biochemical diversity across different districts of Assam

This study examines morphological, seeding, and biochemical diversity in Assam lemon populations across 22 districts in India, revealing clustering patterns and seedless trait distribution.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

The respiratory enzyme complex Rnf is vital for metabolic adaptation and virulence in Fusobacterium nucleatum

This paper identifies the Rnf complex as essential for Fusobacterium nucleatum's metabolic adaptation and virulence, showing its role in amino acid catabolism, biofilm formation, and pathogenesis in a mouse model.

Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly

This study shows that centromere-specifying nucleosomes persist in aging mouse oocytes without new assembly during prolonged prophase I arrest.

Comparing FRET pairs that report on intersubunit rotation in bacterial ribosomes

The paper uses two FRET assays to study intersubunit rotation in bacterial ribosomes, finding spontaneous rotation occurs without EF-G and GTP hydrolysis.

Vitamin D signaling orchestrates skeletal muscle metabolic flexibility by regulating its fuel choice.

This study shows that vitamin D signaling regulates skeletal muscle fuel choice, affecting metabolic flexibility and insulin response to different diets.

Anti-Biofilm Potential of Nanonized Eugenol against Pseudomonas aeruginosa

This study develops eugenol nanoparticles (ENPs) that show enhanced anti-biofilm activity against Pseudomonas aeruginosa compared to bulk eugenol.

Patterns of secondary invasion in the understory of exotic, invasive timber stands

The paper examines patterns of secondary invasion in the understory of exotic invasive tree stands in the Western Ghats Shola Sky Islands, finding strong associations between Eucalyptus and Lantana camara invasions, and environmental factors influencing these patterns.

Electron Videography of a Lipid-Protein Tango

This study uses liquid-phase transmission electron microscopy to image nanoscale lipid-protein interactions in unlabelled membrane protein nanodiscs, revealing long-range lipid effects on nanodisc stability.

Genome-wide investigation of Cytochrome P450 superfamily of Aquilaria agallocha: association with terpenoids and phenylpropanoids biosynthesis

This study identifies and characterizes CYPs in Aquilaria agallocha, linking them to terpenoids and phenylpropanoids biosynthesis and validating their expression in stress-induced tissues.

Cryo-EM structure of the Agrobacterium tumefaciens type IV secretion system-associated T-pilus reveals stoichiometric protein-phospholipid assembly

The paper presents a cryo-EM structure of the Agrobacterium tumefaciens T-pilus, revealing a 1:1 stoichiometric assembly of VirB2 and phosphatidylglycerol with unique electrostatic interactions and structural features.

Conformational Changes Regulate Metal Coordination in the Catalytic Sites of Cas9

This study presents cryo-EM structures of AceCas9 at different states to show how conformational changes regulate metal coordination and catalytic activity.

Photoelectrochemical imaging of action potentials for single cardiomyocytes through contact force manipulation of organoids

This paper introduces a method to monitor action potentials in cardiomyocytes using photoelectrochemical imaging with contact force control, validated with drugs and showing electrophysiological changes.

Nodulin 16 of Lotus japonicus (Nlj16) regulates the recruitment of Leghemoglobin (LegH) to the infected nodule cell membrane during symbiotic nitrogen fixation

This study shows that Nlj16 recruits LegH to the membrane of infected nodule cells, essential for oxygen sequestration during symbiotic nitrogen fixation.

Molecular Mechanism of Active Cas7-11 in Processing CRISPR RNA and Interfering Target RNA

This study presents the cryo-EM structure of Cas7-11, revealing its mechanism for processing CRISPR RNA and cleaving target RNA.