S. Schumacher

This study identifies ERLIN1/2 scaffolds that mediate TMUB1-RNF170 interactions, regulate cholesterol esterification, and maintain ER cholesterol levels to control Golgi morphology and the secretory pathway.

The paper uses single-cell transcriptomics to show how two compartments in medulloblastoma are connected through a migrating precursor stage, revealing spatial and developmental links between proliferating and differentiated tumor cells.

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.