Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7
N. P. Azouz, A. M. Klingler, M. Rochman, M. Paul, J. M. Caldwell, M. Brusilovsky, A. T. Dwyer, X. P. Chen, D. Miller, A. Lynch, C. Forney, L. Kottyan, M. T. Weirauch, M. E. Rothenberg
This study identifies OVOL1 as a regulator of SPINK7 expression in eosinophilic esophagitis, showing AHR activation enhances SPINK7 and barrier function while IL-4 and IL-13 inhibit this pathway.
bioRxiv · May 17, 2023 · PreprintImmunology