M. Paul

Universal Study Design for Instrument Changes in Pharmaceutical Release Analytics

The paper designs a universal study to assess instrument changes in pharmaceutical release analytics, showing that Maurice C performs equal or better than ICE3 in key parameters.

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Precision phenotyping of a barley diversity set reveals distinct drought response strategies

The paper identifies a third drought response strategy in barley, distinct from isohydric and anisohydric, showing unique transpiration dynamics and growth recovery traits.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development

The paper shows that SEPALLATA-driven MADS tetramerization is essential for inner whorl floral organ identity, beyond its role in meristem determinacy.

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

This study identifies OVOL1 as a regulator of SPINK7 expression in eosinophilic esophagitis, showing AHR activation enhances SPINK7 and barrier function while IL-4 and IL-13 inhibit this pathway.

Left or right: Handedness in free-ranging Hanuman langurs (Semnopithecus entellus) residing in an urban ecosystem.

This study examines handedness in free-ranging Hanuman langurs, finding a left-hand bias in adults, challenging the Postural Origin Theory.

Drought and recovery in barley: key gene networks and retrotransposon response.

This study examines drought responses in barley varieties, identifying gene networks and retrotransposon dynamics under drought and recovery conditions.

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

This study identifies the direct interaction between the WW domain of IQGAP1 and the p110α catalytic subunit of PI3K, revealing key residues involved in binding and implications for therapeutic peptide design.

Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

This paper describes the development of a more potent Lats kinase inhibitor, TDI-011536, which promotes cell proliferation and regeneration in mammalian tissues.

CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

This study shows CD169+ macrophages are essential for plasmacytoid dendritic cell arrest and type I IFN priming in malaria-infected mice through TLR7 and STING sensing.

Direct quantification of ligand-induced lipid and protein microdomains with distinctive signaling properties

The paper directly observes ligand-induced GM1 and EphA2 microdomains in live cells and shows differential EphA2 signaling in these domains.

Inferring within-flock transmission dynamics of highly pathogenic avian influenza (H5N8) in France, 2020

This study uses a stochastic epidemic model and ABC-SMC to estimate H5N8 transmission dynamics in ducks, revealing key parameters and latent threats in France in 2020.

Altered food habits? Understanding the feeding preference of free-ranging Grey langur (Semnopithecus entellus) within an urban settlement.

This study examines the feeding preferences of free-ranging grey langurs in an urban setting, finding they prefer urban food items over natural ones due to resource scarcity and human interaction.

A histone-like motif in yellow fever virus contributes to viral replication

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden

This paper develops novel Kras-mutant murine NSCLC models with increased TMB and co-occurring mutations, showing enhanced anti-PD-1 efficacy but immunosuppressed TMEs in some models.