Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice.
D. Thompson, S. Mahmood, N. Morrice…·N. Mody
This study shows that fenretinide reduces obesity and fatty liver but increases ceramides via Smpd3, worsening atherosclerosis in LDLR-/- mice.